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St. Mary's Hospital & Regional Medical Center
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Marty R. Jacobson, PhD

Research Director

Dr. Jacobson is the Research Director and Principal Investigator with the Saccomanno Research Institute at St. Mary's Hospital & Medical Center in Grand Junction, Colorado. Prior to joining the Saccomanno Research Institute, Dr. Jacobson spent 10-years in the biotechnology sector, holding various positions including Group Leader, Director, and VP of R&D. Before this he was a Senior Research Associate and then Laboratory Director at the Worcester Foundation for Biomedical Research, a non-profit research institute in Shrewsbury, MA. Dr. Jacobson received a B.Sc. degree from the University of Wisconsin-Madison, a M.Sc. degree from the University of British Columbia-Vancouver, B.C., and a Ph.D. from North Carolina State University and was an NIH-NSRA Postdoctoral Fellow at the Virginia Polytechnic Institute & State University in Blacksburg, VA.

Research Interests
Research in Dr. Jacobson's laboratory is focused on understanding the molecular processes involved in the initiation and progression of cancer and the identification of biomarkers for early cancer detection, progression, and those useful in evaluating how a patient is responding to cancer therapy.

Current basic and translational research projects being carried out by scientists in Dr. Jacobson's group include the identification and characterization of normal lung and lung cancer stem cells, analysis of the heterogeneity of cells in lung tumors, the role of mitochondrial dynamics in cancer initiation and progression, the effects of ionizing radiation on normal and cancer cells, and the role of alternative splicing in cancer.

Dr. Jacobson also works closely with physicians and staff at St. Mary's Regional Cancer Center to expand both investigator initiated and sponsored (academic and corporate) clinical trails research at St. Mary's Hospital.

Under Dr. Jacobson's direction, the Saccomanno Research Institute maintains a unique biorepository of fully annotated sputum cytology and formalin-fixed, paraffin-embedded (FFPE) tumor specimens collected from a cohort of more than 17,000 uranium miners over an ~45 year period. Because archival tissues and their associated diagnostic records where patient outcomes are known represent an invaluable resource for future biomedical research, the Institute working with St. Mary's Laboratory and Pathology group, has recently initiated efforts to further develop a biorepository around the nearly 50 years of tissue samples available at St. Mary's Hospital. Current research using the uranium miner and other hospital archival samples include retrospective genetic, epigenetic and prognostic signature studies in lung cancer. Most of these studies have been carried out as research collaborations with other academic, non-profit or corporate institutions.

Click PubMed.gov for a listing of publications by Marty R. Jacobson, PhD.

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